Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO
Figure 3
Effect of MARCO on NLRP3 activation using IL-1β as an indicator and OVA as signal 1. IL-1β release from WT and MARCO−/− AM in response to silica (100 μg/mL) cocultured with OVA (10 mg/mL) and with or without cathepsin B inhibitor (10 μM CA-074-Me). Mean ± SEM IL-1β from cultured macrophages where white bars indicate WT AM and grey bars indicate MARCO−/− AM. Asterisk indicates compared to WT, per experimental group.
