Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO

Figure 4

Caspase-1 activation in MARCO ^−/− and WT AM exposed to silica. Caspase-1 activation in WT and MARCO^−/− AM was measured 4 hrs after treatment with silica (100 μg/mL) with or without LPS (20 ng/mL) as described in Methods. Mean ± SEM white bars indicate WT AM and grey bars indicate MARCO^−/− AM. Double asterisk ∗∗ indicates 𝑃<0.01 and triple asterisk ∗∗∗ indicates 𝑃<0.001 compared to WT at corresponding treatment. ## indicates 𝑃<0.01 compared to control in the same mice strain. 𝑛=3 per experimental group.