Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity

Table 3

Association between serum protein levels and the gene-expression levels of the macrophage markers.

	sCD163	IL-6	MCP-1
mRNA
CD14	0.33*	0.23*	0.50**
CD68	0.38**	0.30*	0.34*
CD163	0.37**	0.34*	0.43**
CD206	0.38**	0.28*	0.47**
IL-10	0.37**	0.23*	0.45**
TNF-𝛼	0.22*	0.27*	0.33*
IL-6	0.17	0.25*	0.44*
MCP-1	0.30*	0.28*	0.46**

Subcutaneous AT and blood samples from obese and lean subjects (𝑛=92).
Gene-expression levels of the general macrophage markers: CD14 and CD68, the anti-inflammatory markers: CD163, CD206, and IL-10, and the proinflammatory markers: TNF-𝛼, IL-6 and MCP-1 relative to the house-keeping gene LRP10 measured by RT-PCR. Circulating levels of sCD163, IL-6, and MCP-1 measured by ELISA.
Statistic tests: Spearman’s correlation test; 𝑟: correlations coefficient.
* 𝑃<0.05; **𝑃<0.001.