Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity

Table 4

Multivariate linear regression for HOMA-IR and M1- and M2-macrophage markers.

	Model 1		Model 2
	𝛽	𝑃 value	𝛽	𝑃 value
CD68	—	—	0.01	0.98
CD163	0.57	0.04*	0.57	0.05*
CD206	−0.03	0.89	0.06	0.89
IL-10	−0.47	0.07	−0.07	0.07
TNF-𝛼	0.06	0.71	0.13	0.71
IL-6	−0.06	0.47	−0.03	0.49
MCP-1	0.13	0.79	−0.47	0.80

Subcutaneous AT samples from obese subjects (𝑛=57). Gene-expression levels of mRNA CD68, CD163, CD206, IL-10, TNF-𝛼, MCP-1, and IL-6 measured by RT-PCR. HOMA-IR measured by fasting blood samples. Multivariate linear regression analysis on a log scale. Dependent variable: HOMA-IR. *𝑃<0.05.
Model 1 includes all pro- and anti-inflammatory macrophage markers. Model 2 includes all pro- and anti-inflammatory macrophage markers adjusted to total macrophage number by mRNA CD68.