The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6/IL-10 Axis and Is Associated with the Parasite Load

Figure 1

High levels of IL-6, CXCL-8, IFN-𝛾, IL-5, and IL-10 are found in the circulation of patients infected with P. vivax. The biomarkers IL-1β, IL-6, CXCL-8, TNF-𝛼, IL-12p70, IFN-𝛾, IL-2, IL-4, IL-5, and IL-10 were measured in the serum of healthy donors (open circles) and P. vivax-infected subjects (closed circles). Levels of biomarkers were measured employing ELISA or Cytometric Bead Array (CBA).