Review Article

A New Hope in Immunotherapy for Malignant Gliomas: Adoptive T Cell Transfer Therapy

Table 3

Genetic modification of T cells to improve the efficacy of ACT for cancers.

References

Enhanced specificity
 Expression of α β TCR[16, 17, 136]
 Expression of CARs[1822]
 Coexpression of costimulatory molecules[2325, 137]
Increased survival and proliferation
 Expression of proliferative cytokines[138141]
 Expression of antiapoptotic genes[142144]
 Ectopic expression of gene for telomere elongation (hTERT)[145148]
Enhanced trafficking
 Expression of chemokine receptors[149152]
Enhanced trafficking
 Expression of negative TGF-β receptor[153156]
 Downregulation of Fas[157]
Integration with conventional therapy
 Expression of chemoresistant genes[116]