Review Article
A New Hope in Immunotherapy for Malignant Gliomas: Adoptive T Cell Transfer Therapy
Table 3
Genetic modification of T cells to improve the efficacy of ACT for cancers.
| | References |
| Enhanced specificity | | Expression of α β TCR | [16, 17, 136] | Expression of CARs | [18–22] | Coexpression of costimulatory molecules | [23–25, 137] | Increased survival and proliferation | | Expression of proliferative cytokines | [138–141] | Expression of antiapoptotic genes | [142–144] | Ectopic expression of gene for telomere elongation (hTERT) | [145–148] | Enhanced trafficking | | Expression of chemokine receptors | [149–152] | Enhanced trafficking | | Expression of negative TGF-β receptor | [153–156] | Downregulation of Fas | [157] | Integration with conventional therapy | | Expression of chemoresistant genes | [116] |
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