Multiple Roles of Myd88 in the Immune Response to the Plague F1-V Vaccine and in Protection against an Aerosol Challenge of Yersinia pestis CO92 in Mice
Figure 1
Comparison of the class and subclass antibody titers to the Y. pestis F1-V vaccine in wild-type C3H/NeN, Tlr2, Tlr4, and Tlr2/4 deficient mice after the prime and boost vaccination. Blood was drawn 30 days after each vaccination for the antibody determination (IgG, IgG1, and IgG2a) that is reported as the geometric mean with geometric standard error of the mean. There were 6 mice in each group. There was a significant difference between the wild-type C3H/HeN mice and Tlr2 deficient C3H/HeN mice in the levels of IgG2a after the prime vaccination () and boost vaccination ().
