Multiple Roles of Myd88 in the Immune Response to the Plague F1-V Vaccine and in Protection against an Aerosol Challenge of Yersinia pestis CO92 in Mice
Figure 4
Antibody response to the plague F1-V vaccine in wild-type C57BL/6 and Myd88 deficient mice after the prime and boost vaccination. Serum for the prime vaccination was drawn 22 days after vaccination and for the boost vaccination 29 days after vaccination. All mice received 2 μg of F1-V except mice in the adjuvant only group. N for wild-type C57BL/6 mice with adjuvant and wild-type C57BL/6 mice with F1-V was 6, while for the Myd88 deficient C57BL/6 group with F1-V was 9. The titers are reported as geometric mean with geometric standard error of the mean. Significant differences in the antibody titer between the wild-type C57BL/6 mice that received F1-V and Myd88-deficient C57BL/6 mice that received F1-V which is shown above the respective bar after the prime vaccination (a).
