Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway

Figure 9

Effects of five short peptides on AT1-AAs-induced IL-6 and VCAM-1 expression in endothelial cells. The short peptides were added to cells medium 2 hours before AT1-AAs treatment for 12 hours. And the IL-6 and VCAM-1 expression were determined by Western blot (panel (a)). The five short peptides were P1, VFFIEN; P2, ENTNIT; P3, ITVCAF; P4, AFHYESQ; P5, QNSTLPI. Data were summarized from 5 independent experiments (panel (b)); versus AT1-AAs (control) group, IL-6 expression; versus AT1-AAs (control) group, VCAM-1 expression.

(a)

(b)