Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway

Table 1

Main clinical features of enrolled patients and levels of CRP and AT1-AAs.

Characteristic	Acute coronary syndrome group	Stable coronary disease group	Noncoronary patients group	Control group
Patient number	16	16	16	16
Male (%)	10 (62.5)	9 (56.2)	8 (50)	9 (56.2)
Female (%)	6 (37.5)	7 (43.8)	8 (50)	7 (43.8)
Age y	54 ± 12	63 ± 17	64 ± 12	56 ± 14
Body mass kg	69 ± 12	68 ± 6	66 ± 8	63 ± 10
Smoker (%)	5 (31.2)	6 (37.5)	4 (25%)	5 (31.2)
Systolic blood pressure mmHg	135 ± 14	137 ± 7	148 ± 17	129 ± 4
Plasma fasting glycerin mg/dL	112 ± 17	119 ± 25	121 ± 34	109 ± 9
LDL-cholesterol mg/dL	132 ± 18	126 ± 22	134 ± 23	122 ± 21
Left ventricular eject fraction %	49 ± 10	55 ± 7	57 ± 8	59 ± 5
Serum creatinine mg/dL	1.3 ± 0.4	1.3 ± 0.2	1.4 ± 0.2	1.1 ± 0.2
Coronary disease history^& y	5 ± 4	9 ± 4	—	—
Multicoronary lesion^&, (%)	7 (44)	12 (75)	—	—
CRP level mg/L	5.6 ± 1.76	4.7 ± 0.52	3.0 ± 1.11	2.5 ± 1.05
Positive AT1-AAs (%)	8 (50)	5 (31)	3 (19)	1 (6)
Mean titers of positive serum^&	1 : 124	1 : 53	1 : 50	1 : 40

Statistics signs
Compared to control group, .
^#Compared to noncoronary patients group, .
^&No statistics performed.