Research Article
Analytical and Clinical Comparison of Two Fully Automated Immunoassay Systems for the Diagnosis of Celiac Disease
Table 3
Qualitative agreements between all assays.
| Assay | % PPA (95% CI) | % NPA (95% CI) | % TPA (95% CI) | kappa (95% CI) |
| QF versus FEIA tTG IgA (FEIA equiv = positive) | 98.5 (92.1–100.0) | 99.3 (96.2–100.0) | 99.1 (96.6–99.9) | 0.98 (0.95–1.01) | QF versus FEIA tTG IgA (FEIA equiv = negative) | 100.0 (93.7–100.0) | 92.9 (87.7–96.4) | 94.8 (90.9–97.4) | 0.88 (0.80–0.95) | QF versus FEIA tTG IgG (FEIA equiv = positive) | 75.0 (55.1–89.3) | 96.7 (93.0–98.8) | 93.9 (89.7–96.7) | 0.73 (0.59–0.87) | QF versus FEIA tTG IgG (FEIA equiv = negative) | 80.0 (56.5–94.3) | 94.3 (90.0–97.1) | 92.9 (88.6–96.0) | 0.64 (0.48–0.81) | QF versus FEIA DGP IgA (FEIA equiv = positive) | 93.0 (80.9–98.5) | 91.7 (86.5–95.4) | 92.0 (87.5–95.3) | 0.77 (0.67–0.88) | QF versus FEIA DGP IgA (FEIA equiv = negative) | 90.0 (78.2–96.7) | 94.4 (89.7–97.4) | 93.4 (89.2–96.3) | 0.82 (0.73–0.91) | QF versus FEIA DGP IgG (FEIA equiv = positive) | 98.2 (90.4–100.0) | 96.2 (91.8–98.6) | 96.7 (93.3–98.7) | 0.92 (0.86–0.98) | QF versus FEIA DGP IgG (FEIA equiv = negative) | 100.0 (92.0–100.0) | 89.9 (84.3–94.0) | 92.0 (87.5–95.3) | 0.79 (0.69–0.88) |
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Note: PPA: positive percent agreement, NPA: negative percent agreement, TPA: total percent agreement, QF: QUANTA Flash; FEIA: fluoroenzyme immunoassay.
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