Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate
Figure 3
Antibody concentrations in serum following vaccinations. Animals received three vaccinations at two-week intervals each of 10 μg of either the TetHc-LPS conjugate (∙), LPS alone (■), or a mix of unconjugated LPS and TetHc (▲). Tail bleeds were performed four weeks after the final vaccination and ELISA performed to detect antibodies specific for B. pseudomallei LPS. Data is shown for replicate studies and shows the calculated concentration of total IgG (a), total IgM (b), IgG1 (c), IgG2a (d), and IgG3 (e). Data was analysed by a univariate linear model. Significant differences are shown. Where no markers are present, was greater than 0.05.
