Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target
Figure 6
Cyclopamine decreased Shh and Smo protein expression in cultured RA FLS. Cells were stimulated, treated, and harvested as described in Section 2. Means ± S.D. of 3 independent experiments are shown. Expression of Smo and Shh was significantly lower in cyclopamine-treated FLS than in the control group (). There was no significant difference in Smo and Shh protein expression between Shh stimulated FLS and control cells. versus control group.
