Journal of Immunology Research

Review Article

Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye?

Table 1

FRC characterization markers. FRC was classified by species, surface or intracellular makers, inducible markers and ones that exclude other cells presence, and chemokines and cytokines secretion, listed in time order of publishing.
Publication year—author
(species)		MarkersChemokinesCytokines
SurfaceIntracellularInducibleExcludingRegularInducible
2004—Katakai et al. (a) [11]
(MLN)		CD44, gp38, CD106ER-TR7CD54CD11b/CD18, CD16,CD31, CD32, CD35, MHCII, LYVE1CCL2, CXCL12, CX3CL1CCL4, CCL5, CCL20, CXCL10IL6, IL7, IL15
2004—Katakai et al. (b) [22]
(MLN)		—ER-TR7—————
2005—Sixt et al. [9]
(MLN)		gp38, αSMA, desminER-TR7—————
2006—Bajénoff et al. [23]
(MLN)		Desmin, CD106, CD54 ER-TR7——CCL19, CCL21, CXCL12 (SDF-1)——
2006—Hara et al. [25]
(MLN)		gp38, CD106ER-TR7———CXCL16IL7, IL15
2007—Amé-Thomas et al. [16]
(HT)		CD73, CD90, CD105—CD54
CD106		CD21, CD23, CD35, CD45CCL5, CXCL9, CXCL10, CXCL12CCL19—
2007—Link et al. [4]
(MLN)		gp38, αSMA, desmin, CD157, PDGFRα, PDGFRβ, CD54, CD106, LTβR, TNF-RER-TR7—CD21, CD31, CD35 CD45, LYVE-1CCL19, CCL21—IL7
2009—Roozendaal et al. [30]
(MLN)		gp38ER-TR7 —————
2009—Mueller and Germain [12]
(review)		gp38, PDL1VEGF, ER-TR7—CD45, CD31, CD21, CD35, C4, CD16, CD23, CD32, CD157, Mfge8CCL19, CCL21—IL7
2009—Steel et al. [17]
(NHPLN)		gp38, p75NGFR, TTG, CD54, CD106, CD157, LTβR, PDGFRα, PDGFRβ, αSMA, TNFR1, Meca79, desminER-TR7——CCL19, CCL21, CXCL16, CCL2/MCP1—IL7, IL6
2010—Turley et al. [14]
(review)		gp38, PDL1DEAF1 CD31CCL19, CCL21—IL7
2011—Khan et al. [15]
(MLN)		gp38, PDL1—iNOSCD45, CD31CCL19, CCL21—IL7
2011—Luther et al. [5]
(review)		gp38, CD54, CD106, CD157, PDGFRα β, LTβR, TNFR1, desmin, αSMAVEGF—CD21, CD31, CD35, CD45, C4, Mfge8CCL19, CCL21CCL2, CCL4, CCL5, CXCL12, CXCL16, CX3CL1IL7, IL6
2011—Link et al. [6]
(MHLN)		gp38, CD54, CD106, CD157, PDGFRα β, LTβR, desmin, αSMAERTR7—CD31, CD35, CD45CCL19, CCL21—IL7
2011—Onder et al. [3]
(MLN)		gp38——CD31, CD45CCL19, CCL21—IL7
2011—Fletcher et al. (a) [20]
(MHLN)		gp38, PDGFα, CD54, CD106VEGF—CD45, CD31CCL19, CCL21 CXCL9, CXCL10—IL7
2011—Fletcher et al. (b) [21]
(review)		gp38, PDGFα, CD54, CD106VEGF—CD45, CD31CCL19, CCL21, CXCL12 (SDF1)—IL7
2011—Frontera et al. [37]
(MLN)		CD54, CD106, PDGFα, CD141JAMC—CD45, CD31, LYVE1CCL21——
2011—Siegert et al. [2]
(MLN)		gp38iNOS—CD45, CD35, CD31, EpCAMCCL19, CCL21—IL7
2011—Lukacs-Kornek [34]
(MLN)		gp38, PDL1, INFGR1, TNFR1, TNFR2NOS2, IDO—CD45, CD31CCL19, CCL21——
2012—Zeng et al. [19]
(NHPLN)		Desmin——CD35, CD21———
2012—Siegert and Luther [33]
(review)		gp38, PDL1COX2, Aire, DEAF1, NOiNOS, MHCII, IDO, CD80CD21, CD35, CD31CCL19, CCL21—IL7
2012—Graw and Regoes [26]
(MLN)		————CCL19, CCL21——
2012—Onder et al. [29]
(MLN)		gp38——CD31, CD45CCL19, CCL21—IL7
2012—Hess et al. [13]
(MLN)		gp38, CD106, MadCAM1RankL—CD31, CD45——IL7
2012—Malhotra et al. [28]
(MLN)		gp38, CD140aVEGFA and C, ANGPTL2 and 4, HGF, GREM1, SERPINF1 cadherin-11, IFITM-1, Flt3L—CD31, CD45CXCL14, CCL19, CCL21, CXCL13 CXCL12, CCL2, CCL7 IL34
2012—Acton et al. [24]
(MLN)		gp38——CD31CCL19, CCL21——
2013—Chai et al. [31]
(MLN)		gp38, αSMA, ER-TR7, NO—CD31, CD45CCL19, CCL21—IL-7
2014—Yang et al. [32]
(MLN)		gp38, PDGFRα β, LTβR, αSMAVEGF, iNOS, VEGF, MyD88—CD31, CD45, LYVE-1CCL19, CCL21—IL-7
Murine lymph node (MLN); human tonsils (HT); nonhuman primate lymph node (NHPLN); murine and human lymph node (MHLN).