Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies
Table 1
Clinical and serological data of anti-HMGCR positive sera.
ID
ALBIA (>20)
CIA (>10,000)
ELISA (>20)
Gender
Age
Statin
ADO (ys)
CK* (25–160 U/L)
Necrosis
3
928
201891
149.2
F
62
+
59
1000
+
5
496
213681
113.5
F
53
−
52
13777
+
6
960
259814
193.1
M
59
−
47
8500
+
9
1008
291111
184.9
F
22
−
18
ND
+
10
784
138696
284.3
F
16
−
13
1500
+
11
512
244281
381.8
F
66
+
60
6500
+
13
768
179810
153.5
F
69
+
63
492
Very few fiber
15
320
184190
174.7
F
44
−
21
ND
+
17
800
254442
139.4
F
60
−
54
6000
+
18
1136
218777
126.3
F
53
+
48
4106
+
26
280
119734
57.9
M
67
+
66
5700
+
27
576
180528
88.9
F
17
−
12
17000
+
28
528
288198
93.8
M
65
−
52
500
+
29
84
79904
29.8
F
75
+
73
7429
No biopsy
30
196
135149
49.7
F
72
+
68
3700
+
31
608
250484
324.1
F
35
−
26
5700
+
32
424
141861
932.1
M
81
−
82
ND
+
34
400
208075
118.5
F
84
+
83
4119
ND
37
212
160034
83.3
F
20
−
15
612
+
39
142
115671
56.6
F
67
+
58
2000
−
CK: creatinine kinase; CIA: chemiluminescence immunoassay; ALBIA: addressable laser bead assay; ADO: age at disease onset; ND: not determined.
*Not all CK values are derived from the time point when serum was obtained for anti-HMGCR testing.