Expression of Shelterin Component POT1 Is Associated with Decreased Telomere Length and Immunity Condition in Humans with Severe Aplastic Anemia

Table 3

Shelterin complex mRNA expression in PWBCs [𝑥±𝑠, M (𝑃₂₅--𝑃₇₅)].

Gene	Untreated group (𝑛=9)	Recovering group (𝑛=17)	Control group (𝑛=15)	𝑃 value
POT1	0.29 (0.09–0.58)	0.78 (0.22–2.69)	1.88 (0.93–3.81)	0.0137*
TRF1	0.54 (0.31–0.67)	0.93 (0.35–0.99)	1.00 (0.38–1.05)	0.251
TRF2	1.98 (1.21–2.89)	1.40 (0.82–1.79)	2.10 (1.02–3.11)	0.205
TIN2	3.24 (2.64–3.93)	2.13 (0.81–2.68)	2.23 (0.51–3.92)	0.172
TPP1	1.90 (0.96–2.24)	0.73 (0.40–3.23)	0.70 (0.70–0.78)	0.220
RAP1	3.68 (1.93–4.14)	1.89 (0.61–2.37)	3.86 (0.87–4.18)	0.077

Asterisk means there are significantly differences between untreated group, recovering group, and controls.