Anti-hnRNP B1 (RA33) Autoantibodies Are Associated with the Clinical Phenotype in Russian Patients with Rheumatoid Arthritis and Systemic Sclerosis
Table 1
Characteristics of individuals studied including 397 patients with systemic autoimmune rheumatic diseases and 174 controls.
Diagnosis
Gender f/m
Age median
Age IQR
DD median
DD IQR
Clinical characteristics
RA
165
102/63
54.0
47.0–60.0
0.58
0.3–5.0
Diagnosis was based on ACR/EULAR 2010 criteria, median DAS28: 4.3 (IQR 3.3–5.2)
SPA
58
17/41
37.0
32.0–50.0
7.0
4.5–12.0
52 pts with ankylosing spondylitis according to the New York criteria and 6 pts with axial spondyloarthritis according to the ASAS criteria 2010
JCA
42
26/16
10.6
6.9–15.4
4.4
1.0–9.9
12 pts with polyarticular disease, 24 pts with oligoarticular disease, 6 pts with systemic disease
SLE
50
47/3
36.0
27.0–45.0
5.0
3.0–12.0
Diagnosis was based on ACR 1997 Revisited criteria, median SLEDAI 4.0 (IQR 2.0–8.0)
SSc
65
62/3
53.0
42.0–60.0
5.0
3.0–9.0
Diagnosis was based on ACR (ARA) criteria 1980 Rodnan skin involvement score: median 16 (IQR 9–22), 31 pts with diffuse scleroderma, 27 pts with limited scleroderma, 7 pts with overlap syndrome
SS
17
17/0
62.5
55.0–66.0
5.0
4.0–11.0
Diagnosis was based on American-European classification criteria, median ESSPRI: 5.3 (IQR 3.8–7.0)
HYI (cardiology control)
52
33/19
52.0
44.0–55.0
Clinically observed for absence of rheumatic diseases
BD
122
83/39
33.0
29.5–42.0
ACR: American College of Rheumatology; DAS28: disease activity score of 28 joints; DD: disease duration; ESSPRI: The EULAR Sjögren’s Syndrome Patient Reported Index; EULAR: European League Against Rheumatism; HYI: hyperlipidemic individuals with high Framingham cardiovascular score; JCR: juvenile chronic arthritis; : number; pts: patients; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; SLEDAI: systemic lupus erythematous disease activity index; SPA: spondyloarthropathy; SS: Sjögren’s syndrome; SSc: systemic sclerosis.
