Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis
Table 1
Specific extra-articular manifestations evaluated in patients with RA.
Extra-articular manifestation
Criteria
(1) Pericarditis
Clinical judgment and confirmed by echocardiography
(2) Pleuritis
Clinical judgment and thorax radiographs
(3) Felty’s syndrome
Clinical evidence confirmed by ultrasound and neutropenia <1.8 109 described in at least 2 occasions
(4) Major cutaneous vasculitis
Clinical judgment confirmed by biopsy
(5) Neuropathy
Clinical judgment and positive results poly/mononeuropathy at electromyography
(6) Scleritis, epiescleritis, uveitis, or retinal vasculitis
Identified by an specialist and if required a biopsy was performed
(7) Glomerulonephritis
Corroborated by nephrologist and if required a renal biopsy was performed
(8) Vasculitis involving other organs
Identified by an specialist and if required a biopsy was performed
(9) Amyloidosis
Clinical judgment and positive biopsy if required
(10) Keratoncunjunctivitis sicca
Clinical judgment: (a) positive Rose-Bengal staining and (b) positive Schirmer’s test <5 mm/5 mn
(11) Xerostomia
Clinical judgment and abnormal sialometry and if suspected minor salivary gland biopsy with lymphocytic infiltrate
(12) Secondary Sjögren’s syndrome
Diagnosed by two of the following criteria (a) keratonconjunctivitis sicca, (b) xerostomia, and (c) positivity for anti-Ro or anti-La antibodies
(13) Bronchiolitis obliterans
Clinical judgment by pulmonologist
(14) Organizing Pneumonia
Clinical judgment by pulmonologist
(15) Pulmonary fibrosis
Clinical judgment by pulmonologist plus restrictive pattern in lung function test and confirmed by positive findings in high-resolution computed tomography of the lung
(16) Cervical myelopathy
Clinical judgment and radiograph showing increased in atlantoaxial distance
(17) Subcutaneous rheumatoid nodules
Clinical judgment and biopsy if required
(18) Chronic anemia
Diagnosed if a hemoglobin <11 g/dL was observed in the last 6 months before the evaluation and other causes of anemia were excluded
