The Role of Protein Modifications of T-Bet in Cytokine Production and Differentiation of T Helper Cells

Figure 1

Structure and protein modification of T-bet. Mouse and human T-bet is 100% identical in the T-box domain. Several amino acid residues are conserved in mice and undergo posttranslational modifications, including phosphorylation at serine, threonine, and/or tyrosine residues, and ubiquitination at lysine residues.