Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection

Figure 2

Increased percentages of circulating CXCR5⁺CD4⁺ TFH cells with ICOS^high and PD-1^high expression in peripheral blood of EV71-infected patients. The percentages of CXCR5⁺CD4⁺ TFH cells in the total CD4⁺ T cells (a); the correlation between the percentages of PD-1⁺CXCR5⁺CD4⁺ TFH cells and ICOS⁺CXCR5⁺CD4⁺ TFH cells from EV71-infected patients (𝑛=60) (b); PD-1⁺CXCR5⁺CD4⁺ TFH cells (c) and ICOS⁺CXCR5⁺CD4⁺ TFH cells (d). Data shown were the mean ± SD (standard deviation, SD). The horizontal lines show the median. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001; ns.: no significant difference.

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