Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection

Figure 3

Correlation of specific NAb-EV71 titres and circulating CXCR5⁺CD4⁺ TFH cells with PD-1^high and ICOS^high expression in EV71-infected patients. (a) Titres of specific NAb-EV71 in sera from HC and EV71-infected patients including mild and severe cases. Relationship between the titres of specific NAb-EV71 and the frequency of circulating CXCR5⁺CD4⁺ TFH cells (b), PD-1⁺CXCR5⁺CD4⁺ TFH cells (c), and ICOS⁺CXCR5⁺CD4⁺ TFH cells (d). Data shown were the mean ± SD. The horizontal lines show the median. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001; ns.: no significant difference.

(a)  

(b)

(c)

(d)