Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection

Figure 4

Correlation of cytokines levels and circulating CXCR5⁺CD4⁺ TFH cells in EV71-infected patients including mild and severe cases. (a) Cytokines levels of IL-21 and IL-6 in sera from HC and EV71-infected patients. (b) Relationship between the IL-21 levels and the frequency of circulating CXCR5⁺CD4⁺ TFH cells. (c) Relationship between the IL-6 levels and the frequency of circulating CXCR5⁺CD4⁺ TFH cells. (d) Relationship between the IL-6 levels and IL-21 levels. Data shown were the mean ± SD. The horizontal lines show the median. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001; ns.: no significant difference.

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