Journal of Immunology Research / 2014 / Article / Tab 2 / Research Article
A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent Prognostic/Predictive Factor in Untreated Non-Small Lung Cancer Patients Table 2 Percentages of MDSCs subpopulations in NSCLC patients.
(a) Published subpopulationsMDSC subpopulations (%) (parental gate) NSCLC patients ( = 110) Mean ± SEM Range Median CD33+ CD11b+ (in CD11b+ ) 41.41 ± 2.9 0.2–97.9 40.80 G-MDSC CD14− CD11b+ (lymphocytes excluded) 66.07 ± 3.0 0.7–99.9 74.70 CD14− CD11b+ CD33+ (in CD14− CD11b+ ) 83.25 ± 2.3 3.6–99.9 93.65 CD14− CD15+ CD33+ CD11b+ (in CD14− CD15+ ) 40.27 ± 3.1 0.1–97.3 40.40 M-MDSC CD14+ HLA-DR−/low (in CD14+ ) 25.2 ± 2.1 0.8–83.2 19.01
(b) New subpopulationsMDSC subpopulations (%) (parental gate) NSCLC patients ( = 110) Mean ± SEM Range Median G-MDSC CD14− CD15+ CD33+ CD11b+ HLA-DR− Lin− (in CD14− CD15+ ) 1.97 ± 0.5 0–44 0.65 M-MDSC CD14+ CD15+ CD33+ CD11b+ HLA-DR− Lin− (in CD14+ CD15+ ) 3.55 ± 0.5 0–42 2.10 CD14+ CD15− CD33+ CD11b+ HLA-DR− Lin− (in CD14+ CD15− ) 5.21 ± 0.5 0–21 3.15
M-MDSC: Monocytic Myeloid-Derived Suppressor cells; G-MDSC: Granulocytic Myeloid-Derived Suppressor cells.