The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment

Figure 1

Conceptual illustration of the “Trojan horse” approach to tumor immunotherapy. An immune modulator is delivered directly into a portion of the tumor. That results in inflammation plus “dangerous death”. This results in mobilization of an “army” of tumor specific T cells which then attack the area of the tumor injected plus uninjected areas of tumor, especially if addition agents are provided which promote access of these T cells into these areas and/or local stimulation, for example, agonistic anti-CD40 antibodies.