The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment
Figure 2
Animal study showing how intratumoral therapy induces local regression plus distal regression of uninjected tumor. Intratumoural IL-2 + anti-CD40 is an effective combination against local tumour and untreated distal tumours. C57Bl/6J mice were injected s.c. with 5 × 105 AE17 tumour cells into the left flank and 5 × 105 AE17 cell into the right flank on day 0 and left to develop into large tumours before treatment began. The i.t. treatments were delivered into one tumour indicated by arrows (treated tumour: a), whilst the second (distal) tumour was left untreated (b). Data from 1 experiment (5 or 6 mice/group) is shown as mean ± SEM. Treated mice were compared to PBS-treated controls mice; , (from Jackaman et al., 2008. International Immunology) [29].
