Research Article

Efficacy of Primate Humoral Passive Transfer in a Murine Model of Pneumonic Plague Is Mouse Strain-Dependent

Figure 2

Combined survival plots of 3 studies following passive therapy of mice with either nonimmune or plague vaccinated volunteer serum. Study (1), per group, study (2), per group, and study (3), per group. Mice were administered 250 μL human serum into the peritoneal cavity, 3 hours before being exposed to more than 10 LD50 aerosolised Y. pestis using a modified contained Henderson apparatus. The median time to death (MTD) was calculated using a Kaplan-Meier survival plot.
807564.fig.002