Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen
Figure 3
Lists of top ten GO terms for DEGs in healthy females and males. GO term covers three domains: biological process, cellular component, and molecular function. The left panels showed the GO terms for 358 DEGs in healthy females and males. The right panels showed the GO terms for 116 estrogen-relevant DEGs in healthy females and males. DEGs in healthy females’ and males’ comparison mainly perform DNA-dependent regulation of transcription (TR), biochemical reaction in nucleus, and protein binding and so forth. Estrogen-relevant DEGs widely participated in the cell surface receptor linked signal transduction, biochemical reaction in nucleus, protein binding and so forth.
