Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen

<table>Enriched signaling pathways with significant association with estrogen-relevant DEGs. 116 estrogen-relevant DEGs were subjected to performing of the signaling pathway analysis based on KEGG databases. A group of 30 DEGs are found to be connected functionally, including LEF1, TNFRSF25, PDIA4, PXN, PTGDS, TNFRSF17, KLRC3, TNFSF8, PTGER2, CCR9, PCNA, UPP1, CD8B, CAV1, UNG, PPAP2B, CD2, LOC652346, IFNAR1, BRCA1, IL7R, PML, IL7, PPARA, CCL5, PCK2, CXCR3, DTX3L, RPS4Y1, and TLR7. Blue stars indicate that these 9 DEGs are highly related to the immunoreactions.</table>

Journal of Immunology Research

fig4

Figure 4

Figure 4: Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen 