Research Article

Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen

Table 2

The top 20 upregulated and downregulated differentially expressed genes between healthy females and males (fold change = ratio of healthy females/healthy males).

Gene IDGene Gene description q value (%)Fold Change

Upregulated  
 AF172085CAV1Caveolin 1, caveolae protein2.673175.8121
 BC069661CD200R1 CD200 receptor 14.397885.5199
 NM_020834KIAA1443 KIAA144305.5175
 NM_017878HRASLS2 HRAS-like suppressor 24.218165.3753
 NM_138806CD200R1 CD200 receptor 14.956315.1925
 BC082246CAV1Caveolin 1, caveolae protein2.81694.8298
 NM_001001712LCN10 Lipocalin 103.779264.3216
 NM_006533MIA Melanoma inhibitory activity4.218164.2646
 NM_016095Pfs2 DNA replication complex GINS protein PSF24.956314.2172
 BC058291TNFRSF17Tumor necrosis factor receptor superfamily, member 174.956313.9719
 BC028973MKKSMcKusick-Kaufman syndrome4.397873.9554
 AF469635CXCR3Chemokine (C-X-C motif) receptor 303.9458
 XM_927420LOC653154Similar to brain protein 164.218163.8507
 NM_004650PNPLA4Patatin-like phospholipase domain containing 403.8467
 NM_004925AQP3Aquaporin 3 (Gill blood group)3.168723.7642
 BC014550NT5DC25′-nucleotidase domain containing 203.722
 NM_022908NT5DC25′-nucleotidase domain containing 22.487013.6865
 BC013870GOLPH3LGolgi phosphoprotein 3-like3.779263.6842
 NM_178518GOLPH3LTransmembrane protein 10203.6597
 NM_001504CXCR3Chemokine (C-X-C motif) receptor 32.146453.628
Downregulated  
 NM_004653SMCYSmcy homolog, Y-linked00.0016
 D87072SMCYSmcy homolog, Y-linked00.002
 NM_032576CYorf15B Chromosome Y open reading frame 15B00.0022
 NM_004654USP9YUbiquitin specific peptidase 9, Y-linked (fat facets-like, drosophila)00.0032
 NM_004681EIF1AYEukaryotic translation initiation factor 1A, Y-linked00.0042
 NM_004660DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked00.0046
 NM_001008RPS4Y1Ribosomal protein S4, Y-linked 100.0056
 BC100905RPS4Y1Ribosomal protein S4, Y-linked 100.0059
 NM_003411ZFYZinc finger protein, Y-linked00.0076
 NM_182659UTYUbiquitously transcribed tetratricopeptide repeat gene, Y-linked00.0078
 BC035312CYorf15BChromosome Y open reading frame 15B00.0083
 NM_001005852CYorf15AChromosome Y open reading frame 15A00.0148
 NM_007125UTY“Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked”00.0163
 NM_182660UTY“Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked”00.0176
 AF332239TTTY10“Testis-specific transcript, Y-linked 10”00.0265
 BC034942DDX3Y“DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked”00.0388
 BC067537IL7RInterleukin 7 receptor0.67160990.0418
 NM_002185IL7RInterleukin 7 receptor00.0523
 BC070321CD3D“CD3d molecule, delta (CD3-TCR complex)”00.0614
 NM_000954PTGDSProstaglandin D2 synthase 21 kDa (brain)00.0632