Research Article

Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen

Table 3

The top 20 upregulated and downregulated estrogen-relevant DEGs between healthy females and males (fold change = ratio of healthy females/healthy males).

Gene IDGeneGene descriptionq value (%)Fold Change

Upregulated
 AF172085CAV1Caveolin 1, caveolae protein2.673175.8121
 BC069661CD200R1CD200 receptor 14.397885.5199
 NM_020834KIAA1443KIAA144305.5175
 NM_017878HRASLS2HRAS-like suppressor 24.218165.3753
 NM_138806CD200R1CD200 receptor 14.956315.1925
 BC082246CAV1Caveolin 1, caveolae protein2.81694.8298
 NM_001001712LCN10Lipocalin 103.779264.3216
 NM_006533MIAMelanoma inhibitory activity4.218164.2646
 BC058291TNFRSF17Tumor necrosis factor receptor superfamily, member 174.956313.9719
 BC028973MKKSMcKusick-Kaufman syndrome4.397883.9554
 AF469635CXCR3Chemokine (C-X-C motif) receptor 303.9458
 NM_004925AQP3Aquaporin 3 (Gill blood group)3.168723.7642
 NM_001504CXCR3Chemokine (C-X-C motif) receptor 32.146453.628
 NM_006641CCR9Chemokine (C-C motif) receptor 94.397883.5421
 AY030238LQK1LQK1 hypothetical protein short isoform2.487013.369
 XM_931870LQK1LQK1 hypothetical protein short isoform2.146453.2506
 BC009196PPAP2BPhosphatidic acid phosphatase type 2B4.956313.1285
 NM_000629IFNAR1“Interferon (alpha, beta and omega) receptor 1”1.779773.1025
 D12502CEACAM1Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)4.397882.9871
 NM_198990NAPE-PLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D2.146452.966
Downregulated
 NM_004681EIF1AYEukaryotic translation initiation factor 1A, Y-linked00.0042
 NM_004660DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked00.0046
 NM_001008RPS4Y1Ribosomal protein S4, Y-linked 100.0056
 BC100905RPS4Y1Ribosomal protein S4, Y-linked 100.0059
 NM_003411ZFYZinc finger protein, Y-linked00.0076
 BC034942DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked00.0388
 BC067537IL7RInterleukin 7 receptor0.671610.0418
 NM_002185IL7RInterleukin 7 receptor00.0523
 NM_000954PTGDSProstaglandin D2 synthase00.0632
 BC041463PTGDSProstaglandin D2 synthase00.0656
 CR610092PTGDSProstaglandin D2 synthase 21 kDa (brain)00.0693
 XM_371783LOC202134Hypothetical protein LOC2021342.308890.0905
 NM_002261KLRC3“Killer cell lectin-like receptor subfamily C, member 3”1.377880.0925
 NM_001553IGFBP7Insulin-like growth factor binding protein 700.0937
 NM_004931CD8BCD8b molecule00.0956
 NM_173663NY-REN-7NY-REN-7 antigen1.039280.0996
 BC023576GNLYGranulysin0.847510.1
 NM_001767CD2CD2 molecule00.1021
 AY232658GZMH“Granzyme H (cathepsin G-like 2, protein h-CCPX)”00.1039
 L14542KLRC3“Killer cell lectin-like receptor subfamily C, member 3”2.816900.1063