Research Article

Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen

Table 4

Top ten enriched signaling pathways with significant association with DEGs (healthy females/males).

Number of genes P values

Kegg pathways
 Cytokine-cytokine receptor interaction10
 Natural killer cell mediated cytotoxicity8
 Hematopoietic cell lineage7
 Antigen processing and presentation6
 Primary immunodeficiency5
 Ubiquitin mediated proteolysis5
 Jak-STAT signaling pathway5
 Graft-versus-host disease4
 Acute myeloid leukemia4
 Toll-like receptor signaling pathway4
Biocarta pathways
 NO2-dependent IL 12 Pathway in NK cells5
 Ras-independent pathway in NK cell mediated cytotoxicity5
 IL12 and Stat4 dependent signaling pathway in Th1 development4
 Stathmin and breast cancer resistance to antimicrotubule agents3
 T cytotoxic cell surface molecules3
 T helper cell surface molecules3
 Lck and Fyn tyrosine kinases in initiation of TCR activation3
 CTL mediated immune response against target cells3
 IL 17 signaling pathway3
 T cell receptor and CD3 complex2
Genmapp pathways
 Hs_1-Tissue-Blood_and_Lymph9
 Cell surface receptor linked signal transduction8
 Cellular_process-Hs_T-Cell-Receptor_NetPath_118
 Humoral immune response7
 Inflammatory response7
 Transmembrane receptor activity6
 Humoral defense mechanism (sensu Vertebrata)6
 Isomerase activity6
 Lipid metabolism6
 Hs_TNF-alpha-NF-kB_NetPath_96