Research Article

Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen

Table 5

Top ten enriched signaling pathways with significant association with estrogen-relevant DEGs (healthy females/males).

Number of genesP Value

KEGG pathways
 Cytokine-cytokine receptor interaction9
 Hematopoietic cell lineage4
 Primary immunodeficiency3
 Acute myeloid leukemia3
 Toll-like receptor signaling pathway3
 Ubiquitin mediated proteolysis3
 Jak-STAT signaling pathway3
 Base excision repair2
 Adipocytokine signaling pathway2
 PPAR signaling pathway2
Biocarta pathways
 NO2-dependent IL 12 Pathway in NK cells2
 IL-7 signal transduction2
 Dendritic cells in regulating TH1 and TH2 development2
 Mitochondrial carnitine palmitoyltransferase (CPT) system1
 Basic mechanism of action of PPARa, PPARb(d), and PPARg and effects on gene expression1
 The role of eosinophils in the chemokine network of allergy1
 BRCA1-dependent Ub-ligase activity1
 Arrestins in GPCR desensitization1
 IFN alpha signaling pathway1
 Regulation of PGC-1a1
Genmapp pathways
 Tissue-specific-Hs_1-Tissue-Blood_and_Lymph6
 GO_Samples-Biological process-cell motility5
 GO_Samples-Biological process-locomotion5
 GO_Samples-Biological process-locomotory behavior5
 Contributed-metabolic process-Hs Prostaglandin synthesis regulation3
 GO_Samples-Molecular function-isomerase activity4
 GO_Samples-Biological process-cell surface receptor linked signal transduction4
 GO_Samples-Biological process-humoral immune response4
 GO_Samples-Biological process-inflammatory response4
 GO_Samples-Biological process-response to chemical substance4