An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

Table 1

General information of recombinant PRVs.

Insertion sites in PRV genome	Parental PRV strains	Foreign Genes [references]
TK gene	Bartha-K61 strain	GP5 of PRRSV [24]
TK gene	Bartha-K61 strain	The HA gene of H3N2 subtype SIV [55]
Between PK and gG gene	Bartha-K61 strain	The major immunodominant surface antigen 1 (TgSAG1) of the protozoan parasite, T. gondii [57]
Between PK and gG gene	Bartha-K61 strain	The glycoprotein of rabies virus [61]
Between PK and gG gene	Bartha-K61 strain	The glutathione S-transferase (Sj26GST) and the fatty acid binding protein (SjFABP) of Schistosoma japonicum [59]
gG gene	TK-/gG-/LacZ + strain	The VP1 gene of FMDV [38]
gG gene	TK-/gG-/LacZ + strain	The capsid precursor encoding regions of [39]
gG gene	TK-/gG-/EGFP + strain	The main surface antigen 1 (SAG1) and the micronemal protein MIC3 of the protozoan parasite, T. Gondii [58]
gG gene	TK-/gG-/LacZ + strain	The NS1 gene of Japanese encephalitis virus [60]
gD gene	gE-/gD-strain	The envelope glycoprotein E2 of CSFV [51]
gI gene	TK-/gE-/gI-strain	The VP2 gene [44]
Between gE and gI gene	TK-/gE-/gI-/LacZ + strain	Two major membrane-associated proteins (GP5 and/or M) (GP5 contains a native GP5 and a modified GP5) of PRRSV [11]
Between gE and gI gene	TK-/gE-/LacZ + strain	ORF1 and partial ORF2 gene/ ORF2 gene of PCV2 [10, 31]
Between gE and gI gene	TK-/gE-/gI-strain	The capsid precursor polypeptide P12A and nonstructural protein 3C of FMDV [40]
Between gE and gI gene	TK-/gE-/LacZ + strain	The protein precursor P1-2A of FMDV and VP2 protein of PPV [12]
gE gene	TK-/gE-/LacZ + strain	The modified GP5 [25]