Targeted Inhibition of mTOR Signaling Improves Sensitivity of Esophageal Squamous Cell Carcinoma Cells to Cisplatin

Figure 5

Analysis of total mRNA expressions of mTOR (a), p70S6K (b), and 4EBP1 (c) from EC9706 xenografts treated by different ways. ((d)–(f)) Semiquantitative values of mRNA levels of mTOR, p70S6K, and 4EBP1 to β-actin, respectively. Results from three independently repeated experiments, which were statistically analyzed by densitometry using BandScan 5.0 software, are expressed as means ± SD. The mRNA level of mTOR was downregulated while mRNA levels of p70S6K and 4EBP1 were upregulated after being treated with mTOR siRNA and siRNA + cisplatin. *𝑃<0.05, compared to control group.

(a)

(b)

(c)

(d)

(e)

(f)