The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets
Figure 1
Chemokines influx the tumor microenvironment. (a) CCL19, CCL20, and CCL21 act as chemoattractants for dendritic cells (DC); (b) CX3CL1 has been related to infiltration of DCs as well as activated (cytotoxic) CD8+ T lymphocytes and NK cells. These last two populations are also chemoattracted by (c) CXCL9 and CXCL10. DCs, T CD8+ lymphocytes, and NK cells are thought to contribute to antitumoral immune response. (d) CCL2 and CCL5 are both chemoattractants for monocytes (Mon), which (e) within tumor microenvironment acquire a TAM phenotype. (f) CCL22 expression correlates with Treg infiltration, which together with TAMs promotes tumor survival and progression.
