Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma

Table 1

Frequency of autoantibody against MDM2 in human sera by ELISA.

Type of sera	Number tested	Autoantibody to MDM2 (%)
HCC	244	47 (19.3)
LC	30	0**
CH	30	2 (6.6)**
NHS	89	0**

The cutoff value designating positive reaction was the mean optical density (OD) of 89 normal human sera plus 3 standard deviations (SD); P value relative to NHS (𝑃=0.000), CH (𝑃=0.002), and LC (𝑃=0.000), **𝑃<0.01; HCC: hepatocellular carcinoma; LC: liver cirrhosis; CH: chronic hepatitis; and NHS: normal human sera.