Immunomodulation by Trypanosoma cruzi: Toward Understanding the Association of Dendritic Cells with Infecting TcI and TcII Populations

Figure 3

T. cruzi strains differentially affect the production of pro- and anti-inflammatory cytokines and CCL2. Murine bone marrow-derived DCs were incubated for 18 h with no stimulation (medium), LPS (100 ng/mL), or different T. cruzi strains (MOI 3 : 1), and the production of cytokines and chemokines was evaluated by ELISA. (a) TNF-α. (b) IL-6. (c) IL-12p40. (d) IL-10. (e) CCL2. The bars represent the mean, and the vertical lines represent the standard error. compared with noninfected DCs (medium). # and lines: comparing the strains; Student’s -test or Mann-Whitney test.

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