Immunomodulation by Trypanosoma cruzi: Toward Understanding the Association of Dendritic Cells with Infecting TcI and TcII Populations

Figure 4

T. cruzi strains differentially affect the expression of costimulatory molecules by DCs. Murine bone marrow-derived DCs were incubated for 18 h with no stimulation (medium), LPS (100 ng/mL), or different T. cruzi strains (MOI 3 : 1), and costimulatory molecule expression was evaluated by flow cytometry and represented as % of DCs expressing costimulatory molecules. (a) MHC II. (b) CD83. (c) CD80. (d) CD86. (e) CD40. (f) PD-L1. The bars represent the mean, and the vertical lines represent the standard error. compared with noninfected DCs (medium). # and lines: comparing the strains; Student’s -test or Mann-Whitney test.

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