Immunomodulation by Trypanosoma cruzi: Toward Understanding the Association of Dendritic Cells with Infecting TcI and TcII Populations

Figure 6

T. cruzi strains differentially affect the expression of TLR2 and TLR4 in DCs. Murine bone marrow-derived DCs were incubated for 18 h with no stimulation (medium), LPS (100 ng/mL), or different T. cruzi strains (MOI 3 : 1), and TLR2 or TLR4 expression was evaluated by flow cytometry. ((a) and (c)) Percentage of DCs expressing TLR2 or TLR4. ((b) and (d)) Intensity of TLR2 or TLR4 expression in DCs based on the MFI. The bars represent the mean, and the vertical lines represent the standard error. compared with noninfected DCs (medium). # and lines: comparing the strains; Mann-Whitney test.

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