Journal of Immunology Research / 2015 / Article / Tab 1 / Research Article
The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy Table 1 Clinical and histological characteristics at renal biopsy of the 107 lupus nephritis patients enrolled in the study who received 111 renal biopsies.
Males/females 13/94 Age at diagnosis of renal biopsy (M ± SD) 36.4 ± 13.9 Duration of SLE years (M ± SD) 5.1 ± 6.5 Serum creatinine mg/dL (M ± SD) 1.07 ± 0.76 Number of patients with serum creatinine >1.2 mg/dL 31 (28%) Proteinuria g/24 h (M ± SD) 3.4 ± 2.85 Number of patients with nephrotic syndrome 44 (39.6%) Hemoglobin g/dL 11.53 ± 1.9 Class II (number of patients)/activity index/chronicity index 8 (7.2%)/1.6 ± 3.2/0.4 ± 0.9 Class III (number of patients)/activity index/chronicity index* 35 (31.5%)/5.3 ± 2.5/1.7 ± 1.74 Class IV (number of patients)/activity index/chronicity index** 50 (45%)/9.0 ± 3.2/2.1 ± 1.7 Class V (number of patients)/activity index/chronicity index 18 (16.2%)/1.1 ± 2.1/0.7 ± 1.2 Methylprednisolone pulses 0.5–1 g/day for 3 days*** 80 (72%) Oral prednisone 1 mg/kg/day for 1 month 31 (28%) Oral cyclophosphamide 1-2 mg/kg/day for 2-3 months 36 (32%) 6 fortnightly cyclophosphamide pulses of of 0.5 g 11 (10%) 6 monthly cyclophosphamide pulses of 1 18 (16%) Mycophenolate mofetil 2 g/day$ 20 (18%) Maintenance therapy: mycophenolate mofetil/azathioprine 30/21
M, mean; SD, standard deviation. * including 15 patients with class III + V; ** including 15 patients with class IV + V; *** (1 patient of class II, 27 of class III, 45 of class IV, and 7 of class V); (14 patients of class III and 22 of class IV); (3 patients of class III, 6 of class IV, and 2 of class V); (2 patients of class II, 5 of class III, 10 of class IV, and 1 of class V), $ (2 patients of class II, 5 of class III, 8 of class IV, and 5 of class V).