The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy
Table 2
Comparison of clinical and immunological features between nonproliferative forms (class II + class V) and proliferative forms (class III + class IV) lupus nephritis.
Non proliferative LN 26 patients
Proliferative LN 85 pateints
Serum creatinine mg/dL
0.8 (0.67–0.96)
0.9 (0.74–1.15)
Ns
Proteinuria g/day
1.94 (1–2.74)
2.8 (1.6–4.7)
0.02
Hemoglobin g/dL
12.9 (11.3–14)
11.2 (9.8–12.3)
0.0008
Activity index
1 (0–3)
7 (5–9)
0.0000
Chronicity index
1 (0–2)
2 (1–3)
0.02
Erythrocyte sedimentation rate mm
21 (11–46.5)
37.5 (20.7–71.5)
0.07
C reactive protein mg/dL
0.39 (0.08–0.89)
0.3 (0.11–0.6)
Ns
C3 mg/dL
72 (60–94)
62 (46.7–80.5)
0.02
C3 <90 mg/dL
65%
87.3%
0.08
C4 mg/dL
13 (9–19)
8.5 (5–14)
0.02
C4 <15 mg/dL
57.6%
78.8%
0.01
Anti-DNA antibodies U/mL
67 (18–135)
183 (85–400)
0.001
Anti-DNA antibodies U/mL >50
50%
86%
0.001
Anti-C1q antibodies AU
41 (22–123)
216 (63–320)
0.0005
Anti-C1q antibodies AU >55
44%
79%
0.003
Anti-nucleosome Ab U
51 (18.5–97)
95 (44–118)
0.04
Anti-nucleosome antibodies Ab U >20
68%
84%
0.02
Anti-DNA >50 U/mL or anti-C1q >55 AU
9 (36%)
80 (95%)
0.000
Anti-ribosome antibodies
3 (2–5.5)
2 (2–6)
Ns
Anti-ribosome antibodies >20
16%
13%
Ns
Lupus anti-coagulant positivity
22.7%
15,4%
Ns
Antiphospholipid antibodies
32%
25%
Ns
The data are reported as Median and interquartile ranges.
