The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy
Table 4
Outcome of clinical and immunological parameters at 3, 6, and 12 months after the beginning of induction therapy.
Basal 16 pts
At 3 months
Basal 46 pts
At 6 months
Basal 42 pts
At 12 months
S. Creat. mg/dL
0.76 0.68–1.6
0.76 0.65–0.89
Ns
0.87 0.7–1
0.85 0.7–1
Ns
0.82 0.67–0.96
0.74 0.67–0.93
Ns
Proteinuria g/day
2.5 1.8–4
0.94 0.52–4.2
Ns
2.2 1.3–3.9
0.92 0.3–1.5
0.0000
3.0 2.05–4.9
0.51 0.23–1.26
0.0000
ESR mm
65 25.7–82
36.5 10.5–51.7
0.04
29.5 12–63.7
21.5 14.2–31.2
Ns
33 20–67
13.5 10.2–32.7
0.0003
CRP mg/dL
0.47 0.261.1
0.30 0.2–1.32
Ns
0.29 0.09–0.7
0.1 0.06–0.28
0.005
0.31 0.12–0.61
0.1 0.04–0.2
0.005
C3 mg/dL
67 60–87
83 74.5–100.5
0.03
73 47.2–87.7
92 79–108
0.0000
63 48–81.2
86.5 71–101.5
0.0000
C4 mg/dL
10 8–13
13 9–20
Ns
10 5.2–16.7
17 11–21
0.0000
9 5–14.7
13.5 10–20
0.001
Anti-DNA Ab UmL
79.5 10.0–291
38 11.7–85
0.01
173 69.5.400
71.7 15.7–84.7
0.0000
124 83.7–345
48 34–104
0.0000
Anti-C1q Ab AU
120.5 52–315
52.5 39–121
0.002
94 35–234
50 22.7–108.5
0.0003
147 56–320
65 35.7–122
0.0000
Anti-nucleosome Ab
66 42.7–110
58 39–83
0.04
97.5 30–118
41 13–56
0.0001
88 51–109
32 16–70
0.0001
Anti-ribosome Ab
2.5 1.75–4
2 2-3
Ns
3.5 2–6
2 2–3.5
0.0007
2 2–10
2 2-3
Ns
The data are reported as Median and interquartile ranges: S. = serum, Creat. = creatinine, ESR = erythrocyte sedimentation rate, CPR = C reactive protein, and Ab = antibodies.
