Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor

Figure 4

Intradermal EP vaccination protects BALB/c and BALB-neuT mice against a TUBO challenge. Mice were immunized twice with empty (pVAX, gray line) or ECTM (pVAX-ECTM, black line) plasmid. pVAX-ECTM treated BALB/c mice () display total tumor protection ((a), ,), while control group () develops fast growing tumors within 30 days after challenge ((b), ,). Vaccinated BALB-neuT mice () display a delayed tumor onset ((c), ,) and slower tumor growth (,) with respect to control group (). Each line refers to an individual tumor. Log-rank (Mantel-Cox) test and Student’s -test were used for statistical analysis.

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