Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria

Figure 2

Heat map for changes in gene expression among subjects with uncomplicated malaria. Changes in gene expression with uncomplicated P. falciparum malaria revealed five major expression patterns: [A] genes upregulated at the time of acute illness, [AB] genes upregulated at the times of acute illness and treatment, [B] genes upregulated at the time of treatment, [BC] genes upregulated at the times of treatment and recovery, and [C] genes upregulated at the time of recovery. Based on Gene Ontology (GO) categories, profile A and AB genes were related to the immune response, AB genes to apoptosis, and C genes to immune-modulatory functions. In contrast, similar changes in gene expression were not observed in healthy control subjects without P. falciparum malaria (data not shown). Heat map for changes in gene expression among subjects with uncomplicated Plasmodium falciparum malaria.