Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria

Figure 4

Apoptosis response pathway. Expression of most apoptosis-related genes correlated with the parasitemia. Note that the majority of these genes, including Fas (first apoptosis signal), FasL (Fas Ligand), and TP53 (tumor protein 53), were upregulated in subjects with medium to high parasitemias. In contrast, the BCL2 interacting protein (BNIP) family gene and the BCL2 and BCL2L1 apoptosis inhibitory genes were upregulated in subjects with low parasitemias and downregulated in subjects with medium to high parasitemias.

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