|
| Marker1 | Localization | Expressed by |
|
Involved in establishing Tregs phenotype | FoxP3 | Nucleus | tTregs, pTregs (but not in some subsets), and CD8+ Tregs |
Helios | Nucleus | tTregs, pTregs (occasionally) |
|
Involved in Tregs regulatory activity and markers of active Tregs | IL-2 receptor (CD25) | Membrane (the level of expression is crucial) | tTregs, pTregs (but not in some subsets), and CD8+ Tregs |
CTLA-4 | Membrane (but detectable only intracellularly) | tTregs, pTregs |
TGF-β | Cytoplasm, secreted | pTregs (especially but not exclusively Th3) |
IL-10 | Cytoplasm, secreted | pTregs (especially Tr1) |
Granzyme B | Cytoplasm, secreted | tTregs, pTregs |
Perforin | Cytoplasm, secreted | tTregs |
IL-35 | Cytoplasm, secreted | pTregs (occasionally) |
E5NT (CD73) | Membrane | pTregs |
ENTPD1 (CD39) | Membrane | pTregs |
PD-1 ligand (PD-L1) | Membrane | pTregs |
|
Other markers of active Tregs | GITR (CD357) | Membrane | tTregs, pTregs, and CD8+ Tregs |
T-cell Ig and mucin domain protein-3 (Tim-3) | Membrane | tTregs, pTregs |
Galectin-9 | Membrane | tTregs, pTregs |
ICOS (CD278) | Membrane | pTregs |
latency-associated peptide (LAP) | Membrane | tTregs |
CD69 (C-type lectin receptor) | Membrane | pTregs |
|
Involved in tTregs differentiation | IL-2 receptor (CD25) | Membrane | tTregs |
GITR (CD357) | Membrane | tTregs |
OX40 (CD134) | Membrane | tTregs |
TNFR2 | Membrane | tTregs |
|
Involved in pTregs differentiation/expansion and tTregs expansion | IL-2 receptor (CD25) | Membrane | tTregs, pTregs (but not in some subsets) |
CD28 | Membrane | tTregs, pTregs |
GITR (CD357) | Membrane | tTregs, pTregs, and CD8+ Tregs |
OX40 (CD134) | Membrane | tTregs, pTregs |
ICOS (CD278) | Membrane | pTregs |
LAG-3 (CD223) | Membrane | tTregs, pTregs |
Programmed cell death (PD)-1 | Membrane | pTregs |
PD-1 ligand (PD-L1) | Membrane | pTregs |
CD226 | Membrane | pTregs (Tr1) |
CD69 (C-type lectin receptor) | Membrane | pTregs |
|
Involved in inhibition of Tregs activity | GITR (CD357) | Membrane | tTregs, pTregs, and CD8+ Tregs |
OX40 (CD134) | Membrane | tTregs, pTregs |
4-1BB (CD137) | Membrane | tTregs, pTregs |
|
Other markers | CD45R0 (memory marker) | Membrane | tTregs (those expanded), pTregs |
CD45RA (naïve marker) | Membrane | tTregs |
Neuropilin-1 (VEGF receptor) | Membrane | tTregs, low expression in pTregs |
CD49b | Membrane | pTregs (Tr1) |
|
Not expressed by Tregs | IL-7 receptor (CD127) | Membrane | tTregs |
CD49d | Membrane | tTregs |
|