Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis

Figure 2

Balanced modulation of LBP-effect by LBP blockade and G-CSF pretreatment in sepsis. (a) on one hand, LBP promotes bacterial clearance, but on the other hand, it contributes to the sensitization of inflammatory response via activation of NF-κB signaling pathway. (b) Interfering with the LBP-mediated inflammatory response by LBP blockade reduces the inflammatory injury and improves outcome after septic insult.

(a)

(b)