A Novel PET Imaging Using ⁶⁴Cu-Labeled Monoclonal Antibody against Mesothelin Commonly Expressed on Cancer Cells

Figure 7

Representative PET images of mice bearing CFPAC-1, BxPC-3, and PANC-1. (a) A 3D volume rendering CT image of a mouse and a scheme showing the direction of PET images. The positions of xenografts and cross sections are shown on the CT image. CFPAC-1, BxPC-3, and PANC-1 xenografts were at the right shoulder, the left femur, and the right femur, respectively. (b) Serial PET/CT images of the nude mice at 0, 24, and 48 hours after administration of ⁶⁴Cu-DOTA-11-25 mAb and (c) ⁶⁴Cu-DOTA-anti-KLH mAb. Upper panels showed maximum intensity projections (MIP) of whole bodies. Lower panels are transverse PET/CT images at the position of tumors. Upper images (U) showed center of CFPAC-1 (CF), and lower images (L) showed BxPC-3 (Bx) and PANC-1 (P).

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