GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis

Table 5

Characteristics associated with allele G of the GDF15 rs1058587 SNP in RA patients.

Variable	Allele G (GG/CG)	Allele C (CC)		value
	98/310 (31.6)	212/310 (68.3)
	Median (IQR)	Median (IQR)
Age (y)	49.398 (12.46)	53.986 (11.976)		0.001
Age at onset (y)	37.469 (11.513)	41.344 (12.59)		0.008
Variable	Allele G	Allele C	OR (95% CI)	value
	(%)	(%)
Clinical cluster 1^&	72/98 (73.46)	129/212 (60.84)	2.88 (1.16–9.32)	0,0145
ANA (+)	15/98 (15.30)	16/212 (7.54)	2.72 (1.15–8.21)	0,0203
Sjögren’s syndrome	4/98 (4.08)	26/212 (12.26)	0.28 (0.11–0.91)	0,0209
Time cluster 1^#	32/98 (32.63)	98/212 (46.22)	0.52 (0.31–0.92)	0,0228
CVD	41/98 (41.88)	89/212 (41.98)		NS

ANA: anti-nuclear antibodies; CVD: cardiovascular disease; IQR: interquartile range; RA: rheumatoid arthritis.
^&Clinical cluster 1 corresponds to patients with the highest frequency of comorbidity, with moderate frequency of EAM, and without Sjögren’s syndrome.
^#Time cluster 1 corresponds to patients with later age at onset and shorter duration of the disease.