Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use

Figure 7

Nucleotide composition of the tail affects ODN’s immunostimulatory activities. Human PBMCs were stimulated with the indicated synthetic ODNs (1 μM) for 24 hours. IFN-α and IL-6 production in the supernatants were examined by ELISA. Of note, D35-dNs40 (number 10) did not induce substantial IFN-α production.